Association of Cell-adhesion Activities with Virulence in Shiga toxin-producing Escherichia coli O103:H2

被引：2
|
作者：
Kobayashi, Naoki [1 ]
Maeda, Eriko [2 ]
Saito, Shioko [3 ]
Furukawa, Ichiro [4 ]
Ohnishi, Takahiro [1 ]
Watanabe, Maiko [1 ]
Terajima, Jun [1 ]
Hara-Kudo, Yukiko [1 ]
机构：
[1] Natl Inst Hlth Sci, Setagaya Ku, 1-18-1 Kamiyoga, Tokyo 1588501, Japan
[2] Fukuoka Inst Hlth & Environm Sci, 39 Mukaizano, Fukuoka 8180135, Japan
[3] Akita Res Ctr Publ Hlth & Environm, 6-6 Senshu, Kubota, Akita 0100874, Japan
[4] Kanagawa Prefectural Inst Publ Hlth, 1-3-1 Shimomachiya, Chigasaki, Kanagawa 2530087, Japan
来源：
BIOCONTROL SCIENCE | 2016年 / 21卷 / 01期
关键词：
Shiga toxin-producing Escherichia coli; Serotype O103:H2; Virulence; Adhesion activity; Caco-2; cells; STRAINS; O157H7; ADHERENCE; O157-H7; HUMANS; PROFILES; PROTEASE; DISEASE; PCR;
D O I：
10.4265/bio.21.57
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The characteristics of 11 strains of Stx1-producing and Stx2-non-producing STEC O103:H2 were analyzed to investigate the differences in virulence in a single serotype of Shiga toxin (Stx)-producing Escherichia coli (STEC). Differences in the cell-adhesion activity to Caco-2 cells were observed among the strains. The activity of the one strain, isolated from a patient with hemolytic uremic syndrome was 4-20-fold higher than those of the other strains. Although the strains with high cell-adhesion activity showed high expressions of eae, espB, espD, and tir in the locus of enterocyte effacement related with cell-adhesion, those were not specific for this strain. In addition, the Stx1 production level of the strain was not particularly high. It was indicated that the high adhesion activity might be a potential factor to associate serious symptom.
引用
收藏
页码：57 / 61
页数：5
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