Polymer-drug conjugates as nanomedicine: a review

被引：36

作者：

Girase, Monika Lotansing ^{[1
]}

Patil, Priyanka Ganeshrao ^{[1
]}

Ige, Pradum Pundlikrao ^{[1
]}

机构：

[1] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut, Shirpur, Maharashtra, India

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2020年 / 69卷 / 15期

关键词：

Drug targeting; linkers; nanocarriers; polymer-drug conjugate; tumor; HYALURONIC ACID-PACLITAXEL; PHASE-I; POLY(ETHYLENE GLYCOL); TARGETED DELIVERY; TRANSFERRIN RECEPTOR; CANCER-CHEMOTHERAPY; ANTICANCER ACTIVITY; TUMOR ACCUMULATION; CONTROLLED-RELEASE; MOLECULAR-WEIGHT;

D O I：

10.1080/00914037.2019.1655745

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The majority of anti-cancer drugs show poor water solubility and produce adverse effects in healthy tissue. The combination of polymer technology and targeted drug delivery system may overlay the way for more effective yet safer therapeutic options for cancer therapy. Polymer drug conjugate are the polymer based prodrugs designed to increase the aqueous solubility of anti-cancers drugs, subsequently enhance the bioavailability. This update introduced basic concept of polymer drug conjugates (PDC) (prodrug) and provided an overview on currently used synthetic strategies for PDCs. In addition, brief overview on various polymer-drug conjugates updating their clinical status and highlights with major anticipated clinical application in cancer therapy.

引用

页码：990 / 1014

页数：25

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