Classification of the Zoonotic Hepatitis E Virus Genotype 3 Into Distinct Subgenotypes

被引：36

作者：

Nicot, Florence ^{[1
]}

Dimeglio, Chloe ^{[1
,2
]}

Migueres, Marion ^{[1
,2
]}

Jeanne, Nicolas ^{[1
]}

Latour, Justine ^{[1
]}

Abravanel, Florence ^{[1
,2
,3
]}

Ranger, Noemie ^{[1
]}

Harter, Agnes ^{[1
]}

Dubois, Martine ^{[1
]}

Lameiras, Sonia ^{[4
]}

Baulande, Sylvain ^{[4
]}

Chapuy-Regaud, Sabine ^{[1
,2
,3
]}

Kamar, Nassim ^{[2
,3
,5
]}

Lhomme, Sebastien ^{[1
,2
,3
]}

Izopet, Jacques ^{[1
,2
,3
]}

机构：

[1] CHU Toulouse, Lab Virol, Hop Purpan, Ctr Natl Reference Virus Hepatite E, Toulouse, France

[2] INSERM, U1043, Toulouse, France

[3] Univ Toulouse III Paul Sabatier, Dept Virol, Toulouse, France

[4] Inst Curie Res Ctr, Inst Curie Genom Excellence Platform, Paris, France

[5] CHU Toulouse, Hop Rangueil, Serv Nephrol Dialyse & Transplantat Organe, Toulouse, France

来源：

FRONTIERS IN MICROBIOLOGY | 2021年 / 11卷

关键词：

HEV-3; subtype; classification; diversity; full-length genome; phylogeny;

D O I：

10.3389/fmicb.2020.634430

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis E virus (HEV) genotype 3 is the most common genotype linked to HEV infections in Europe and America. Three major clades (HEV-3.1, HEV-3.2, and HEV-3.3) have been identified but the overlaps between intra-subtype and inter-subtype p-distances make subtype classification inconsistent. Reference sequences have been proposed to facilitate communication between researchers and new putative subtypes have been identified recently. We have used the full or near full-length HEV-3 genome sequences available in the Genbank database (April 2020; n = 503) and distance analyses of clades HEV-3.1 and HEV-3.2 to determine a p-distance cut-off (0.093 nt substitutions/site) in order to define subtypes. This could help to harmonize HEV-3 genotyping, facilitate molecular epidemiology studies and investigations of the biological and clinical differences between HEV-3 subtypes.

引用

页数：8

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