Specific inhibition of Stat3 signal transduction by PIAS3

被引：795
|
作者：
Chung, CD
Liao, JY
Liu, B
Rao, XP
Jay, P
Berta, P
Shuai, K
机构：
[1] UNIV CALIF LOS ANGELES,DEPT MED,DIV HEMATOL ONCOL,LOS ANGELES,CA 90095
[2] CTR RECH BIOCHIM MACROMOL,F-34000 MONTPELLIER,FRANCE
[3] UNIV CALIF LOS ANGELES,INST MOL BIOL,LOS ANGELES,CA 90095
[4] UNIV CALIF LOS ANGELES,DEPT BIOL CHEM,LOS ANGELES,CA 90095
来源：
SCIENCE | 1997年 / 278卷 / 5344期
关键词：
D O I：
10.1126/science.278.5344.1803
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The signal transducer and activator of transcription-3 (Stat3) protein is activated by the interleukin 6 (IL-6) family of cytokines, epidermal growth factor, and leptin. A protein named PIAS3 (protein inhibitor of activated STAT) that binds to Stat3 was isolated and characterized. The association of PIAS3 with Stat3 in vivo was only observed in cells stimulated with ligands that cause the activation of Stat3. PIAS3 blocked the DNA-binding activity of Stat3 and inhibited Stat3-mediated gene activation. Although Stat1 is also phosphorylated in response to IL-6, PIAS3 did not interact with Stat1 or affect its DNA-binding or transcriptional activity. The results indicate that PIAS3 is a specific inhibitor of Stat3.
引用
收藏
页码：1803 / 1805
页数：3
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