The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology

被引：13

作者：

Liu, Qiang ^{[1
]}

Niu, Na ^{[2
]}

Wada, Youichiro ^{[3
,4
]}

Liu, Ju ^{[1
]}

机构：

[1] Shandong Univ, Shandong Prov Qianfoshan Hosp, Med Res Ctr, 16766 Jingshi Rd, Jinan 250014, Peoples R China

[2] Shandong Univ, Shandong Prov Hosp, Dept Pediat, 324 Jingwu Rd, Jinan 250021, Peoples R China

[3] Univ Tokyo, Res Ctr Adv Sci & Technol, 4-6-1 Komaba, Tokyo 1538904, Japan

[4] Univ Tokyo, Isotope Sci Ctr, Meguro Ku, 4-6-1 Komaba, Tokyo 1538904, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 02期

基金：

中国国家自然科学基金;

关键词：

CIZ1; DNA replication; alternative splicing; cell cycle; PRIMARY CERVICAL DYSTONIA; CELL-CYCLE CONTROL; CANCER-CELLS; ALZHEIMERS-DISEASE; SUBNUCLEAR DISTRIBUTION; ACIDIC DOMAIN; BREAST-CANCER; GENE; EXPRESSION; MUTATIONS;

D O I：

10.3390/ijms17020212

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cdkn1A-interacting zinc finger protein 1 (CIZ1) was first identified in a yeast-2-hybrid system searching for interacting proteins of CDK2 inhibitor p21(Cip1/Waf1). Ciz1 also binds to CDK2, cyclin A, cyclin E, CDC6, PCNA, TCF4 and estrogen receptor-. Recent studies reveal numerous biological functions of CIZ1 in DNA replication, cell proliferation, and differentiation. In addition, splicing variants of CIZ1 mRNA is associated with a variety of cancers and Alzheimer's disease, and mutations of the CIZ1 gene lead to cervical dystonia. CIZ1 expression is increased in cancers and rheumatoid arthritis. In this review, we will summarize the biological functions and molecular mechanisms of CIZ1 in these physiological and pathological processes.

引用

页数：12

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