Pancreatic cancer is suppressed by fibroblast-derived collagen I

被引：10
|
作者：
Madsen, Chris D. [1 ]
机构：
[1] Lund Univ, Div Translat Canc Res, Dept Lab Med, Lund, Sweden
来源：
CANCER CELL | 2021年 / 39卷 / 04期
基金：
瑞典研究理事会;
关键词：
D O I：
10.1016/j.ccell.2021.02.017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Clinical implementation of anti-stromal therapies in pancreatic cancer has been delayed by unanticipated tumor-restraining properties of the desmoplastic stroma. In confronting these challenges, Chen et al. demonstrate in this issue of Cancer Cell that fibroblast-specific deletion of collagen I, in the background of oncogenic Kras-induced spontaneous murine pancreatic ductal adenocarcinoma, enhances immune suppression and accelerates progression of disease.
引用
收藏
页码：451 / +
页数：4
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