The Roles of Osteopontin in the Pathogenesis of West Nile Encephalitis

被引：2

作者：

Nazneen, Farzana ^{[1
]}

Bai, Fengwei ^{[1
]}

机构：

[1] Univ Southern Mississippi, Dept Cell & Mol Biol, Ctr Mol & Cellular Biosci, Hattiesburg, MS 39406 USA

来源：

VACCINES | 2020年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

osteopontin; West Nile virus; encephalitis; pathogenesis; POSTTRANSLATIONAL MODIFICATIONS; INTRACELLULAR OSTEOPONTIN; VIRUS-INFECTION; EXPRESSION; THROMBIN; CELLS; ALPHA(9)BETA(1); INFLAMMATION; DISEASE; NEUROPROTECTION;

D O I：

10.3390/vaccines8040748

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Osteopontin (OPN), a multifunctional protein encoded by the secreted phosphoprotein-1 (Spp-1) gene in humans, plays important roles in a variety of physiological conditions, such as biomineralization, bone remodeling and immune functions. OPN also has significant roles in the pathogenesis of autoimmune, allergy and inflammatory diseases, as well as bacterial, fungal and viral infections. West Nile virus (WNV), a mosquito-transmitted flavivirus, is the leading agent for viral encephalitis in North America. Recent progress has been made in understanding both the biological functions of OPN and the pathogenesis of WNV. In this review article, we have summarized the current understanding of the biology of OPN and its vital roles in the pathogenesis of WNV encephalitis.

引用

页码：1 / 12

页数：12

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