Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)

被引：55

作者：

Nathan, Pradeep J. ^{[1
,2
]}

Lim, Yen Ying ^{[3
]}

Abbott, Rosemary ^{[4
]}

Galluzzi, Samantha ^{[5
]}

Marizzoni, Moira ^{[5
]}

Babiloni, Claudio ^{[6
,7
]}

Albani, Diego ^{[8
]}

Bartres-Faz, David ^{[9
,10
]}

Didic, Mira ^{[11
,12
]}

Farotti, Lucia ^{[13
]}

Parnetti, Lucilla ^{[13
]}

Salvadori, Nicola ^{[13
]}

Mueller, Bernhard W. ^{[14
]}

Forloni, Gianluigi ^{[8
]}

Girtler, Nicola ^{[15
]}

Hensch, Tilman ^{[16
]}

Jovicich, Jorge ^{[17
]}

Leeuwis, Annebet ^{[18
]}

Marra, Camillo ^{[19
]}

Luis Molinuevo, Jose ^{[10
,20
]}

Nobili, Flavio ^{[15
]}

Pariente, Jeremie ^{[21
]}

Payoux, Pierre ^{[21
]}

Ranjeva, Jean-Philippe ^{[11
,12
]}

Rolandi, Elena ^{[5
]}

Rossini, Paolo Maria ^{[19
]}

Schoenknecht, Peter ^{[16
]}

Soricelli, Andrea ^{[22
]}

Tsolaki, Magda ^{[23
]}

Visser, Pieter Jelle ^{[18
]}

Wiltfang, Jens ^{[14
,24
]}

Richardson, Jill C. ^{[25
]}

Bordet, Regis ^{[26
]}

Blin, Olivier ^{[27
]}

Frisoni, Giovanni B. ^{[5
,28
,29
]}

机构：

[1] Heptares Therapeut Ltd, Cambridge, England

[2] Univ Cambridge, Dept Psychiat, Brain Mapping Unit, Cambridge, England

[3] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[4] Cambridge Cognit, Cambridge, England

[5] IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy

[6] Univ Roma La Sapienza, Dept Physiol & Pharmacol, Rome, Italy

[7] IRCCS San Raffaele Pisana Rome, Rome, Italy

[8] Mario Negri Inst Pharmacol Res, Dept Neurosci, Milan, Italy

[9] Univ Barcelona, Fac Med, Dept Psychiat & Clin Psychobiol, Barcelona, Spain

[10] IDIBAPS, Barcelona, Spain

[11] Aix Marseille Univ, INSERM, INS UMR S 1106, Marseille, France

[12] APHM Hop Timone Adultes, Serv Neurol & Neuropsychol, Marseille, France

[13] Univ Perugia, Osped Santa Maria Misericordia, Ctr Disturbi Memoria, Clin Neurol, Perugia, Italy

[14] Univ Duisburg Essen, Fac Med, LVR Hosp Essen, Dept Psychiat & Psychotherapy, Essen, Germany

[15] Univ Genoa, Neurol Clin, Dept Neurosci DINOGMI, Genoa, Italy

[16] Univ Leipzig, Dept Psychiat & Psychotherapy, Leipzig, Germany

[17] Univ Trento, Ctr Mind Brain Sci, Trento, Italy

[18] Vrije Univ Amsterdam Med Ctr, Alzheimer Ctr, Dept Neurol, Amsterdam, Netherlands

[19] Catholic Univ, Policlin A Gemelli Fdn, Inst Neurol, Dept Gerontol Neurosci & Orthoped, Rome, Italy

[20] Hosp Clin Barcelona, Alzheimers Dis Unit & Other Cognit Disorders Unit, Barcelona, Spain

[21] INSERM, Imagerie Cerebrale & Handicaps Neurol UMR 825, Toulouse, France

[22] SDN Ist Ric Diag & Nucl, Naples, Italy

[23] Aristotle Univ Thessaloniki, G Papanikolaou Hosp, Med Sch, Neurol Clin 3, Thessaloniki, Greece

[24] Georg August Univ, Univ Med Ctr UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany

[25] GlaxoSmithKline R&D, Neurosci Therapeut Area, Stevenage, Herts, England

[26] Univ Lille, INSERM, CHU Lille, U1171 Degenerat & Vasc Cognit Disorders, Lille, France

[27] Aix Marseille Univ, UMR CNRS 6193, Mediterranean Inst Cognit Neurosci INCM, Marseille, France

[28] Univ Hosp, Memory Clin & LANVIE Lab Neuroimaging Aging, Geneva, Switzerland

[29] Univ Geneva, Geneva, Switzerland

来源：

NEUROBIOLOGY OF AGING | 2017年 / 53卷

关键词：

Mild cognitive impairment; Prodromal; Alzheimer's disease; Cognitive assessment; CANTAB; CSF; Amyloid; Tau; Hippocampal volume; PRODROMAL ALZHEIMERS-DISEASE; HEALTHY OLDER-ADULTS; HIGH AMYLOID-BETA; A-BETA; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; STRUCTURAL MRI; BRAIN; DECLINE; MEMORY;

D O I：

10.1016/j.neurobiolaging.2017.01.013

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) A beta 42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of A beta 42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/A beta 42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Ab and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：1 / 10

页数：10

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