Anticoagulation after liver transplantation: a retrospective audit and case-control study

被引：6
|
作者：
Widen, Anna [1 ]
Rolando, Nancy [1 ]
Manousou, Pinelopi [1 ]
Rolles, Keith [1 ]
Davidson, Brian [1 ]
Sharma, Dinesh [1 ]
Tuddenham, Edward [2 ]
Burroughs, Andrew K. [1 ]
机构：
[1] Royal Free Hosp, Sheila Sherlock Hepatobiliarypancreat & Liver Tra, London NW3 2QG, England
[2] Royal Free Hosp, Haemophilia Unit, London NW3 2QG, England
来源：
BLOOD COAGULATION & FIBRINOLYSIS | 2009年 / 20卷 / 08期
关键词：
anticoagulation; bleeding; fibrosis; liver transplantation; warfarin; FACTOR-V-LEIDEN; FIBROSIS; CIRRHOSIS; THROMBOSIS; THERAPY; TERM;
D O I：
10.1097/MBC.0b013e32832c87c8
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Anticoagulation may in the future become a therapeutic option for the prevention of liver fibrosis, such as due to recurrent hepatitis C virus infection after liver transplantation. Currently, there are other indications for anticoagulation after liver transplantation but no data regarding its safety. The objective of the study was to audit the safety of anticoagulation after liver transplantation. Liver transplant recipients receiving anticoagulation postoperatively were compared with a matched control group with respect to bleeding complications and postoperative course. Anticoagulation did not increase the risk of bleeding complications after liver transplantation. On the basis of safety, it appears feasible to use anticoagulation in trials to assess prevention of liver fibrosis. Blood Coagul Fibrinolysis 20:615-618 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
引用
收藏
页码：615 / 618
页数：4
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