Banana Peel Extract Suppressed Prostate Gland Enlargement in Testosterone-Treated Mice

被引：13
|
作者：
Akamine, Kiichiro [1 ]
Koyama, Tomoyuki [1 ]
Yazawa, Kazunaga [1 ]
机构：
[1] Tokyo Univ Marine Sci & Technol, Grad Sch Marine Sci & Technol, Lab Nutraceut & Funct Foods Sci, Minato Ku, Tokyo 1088477, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2009年 / 73卷 / 09期
关键词：
suppressive effect on benign prostate hyperplasia; inhibitor of 5alpha-reductase; banana peel extract; anti-androgen effect; mice; 5-ALPHA-REDUCTASE INHIBITOR; STEROID; 5-ALPHA-REDUCTASE; ANTAGONIST FLUTAMIDE; BULIMIA-NERVOSA; DOSE-RESPONSE; CELL-GROWTH; FINASTERIDE; HYPERPLASIA; FRUIT; ASSAY;
D O I：
10.1271/bbb.80770
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-responsive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.
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页码：1911 / 1914
页数：4
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