Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans

被引：8

作者：

Zhang, Yu ^{[1
]}

Bai, Xue ^{[1
]}

Yuwen, Huan-Sha ^{[1
]}

Guo, Ling-Li ^{[1
]}

Liu, Jian-Wen ^{[1
]}

Hao, Xiao-Jiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2021年 / 107卷

基金：

中国国家自然科学基金;

关键词：

Tabernaemontana divaricate; Taberdines A-K; Reversal of fluconazole resistance; Candida albicans;

D O I：

10.1016/j.bioorg.2020.104515

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nineteen indole alkaloids including eleven new ones, taberdines A-K (1-11), were isolated from Tabernaemontana divaricata. Their structures were assigned by MS, NMR, single crystal X-ray diffractions, and ECD analyses. Alkaloid 1 is an aspidosperma-type monoterpenoid indole alkaloid and possesses a rearranged pyrrolidine moiety due to C-3 degradation, and 4 has a rare 1,3-oxazolidine moiety within iboga-type alkaloids. Alkaloids 2, 4, 6, and 11-19 combined with 5 mu g/mL fluconazole exhibited significant activity to reverse fluconazole resistance in Candida albicans strains while no one used alone showed any activities against the resistant strain.

引用

页数：8

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