Correlation between in vitro secretion of virulence-associated proteins of Campylobacter jejuni and colonization of chickens

被引：21

作者：

Biswas, D. ^{[1
]}

Fernando, U. M. ^{[1
]}

Reiman, C. D. ^{[1
]}

Willson, P. J. ^{[1
]}

Townsend, H. G. G. ^{[1
]}

Potter, A. A. ^{[1
]}

Allan, B. J. ^{[1
]}

机构：

[1] Univ Saskatchewan, Vaccine & Infect Dis Org, Saskatoon, SK S7N 5E3, Canada

来源：

CURRENT MICROBIOLOGY | 2007年 / 54卷 / 03期

关键词：

D O I：

10.1007/s00284-006-0295-z

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mechanisms used by Campylobacter jejuni to colonize the (chicken) intestinal tract have not been defined. In this study, we obtained evidence that in the presence of chicken serum and mucus, C. jejuni secreted proteins that may play a role in the colonization of chicken gut (Campylobacter invasion antigen = Cia). C. jejuni strains NCTC11168V1 and 81-176, as well as an NCTC11168V1 flaA mutant, were found to colonize intestinal tract and secrete proteins in the presence of chicken mucus, chicken serum, or fetal bovine serum in cell culture-conditioned medium. C. jejuni strain NCTC11168V26, which was observed to be a poor colonizer compared with the other C. jejuni isolates, did not secrete Cia proteins. Secreted proteins were also recognized by Western immunoblot using sera from birds that had been colonized by C. jejuni. These data suggest that C. jejuni secretes Cia proteins during colonization of chicken gut and that these Cia proteins play an important role in colonization.

引用

页码：207 / 212

页数：6

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