An expedient approach for the synthesis of pyrrolo[3,2-d]pyrimidines (9-deazaxanthines) and furo[3,2-d]pyrimidine via radical cyclization

被引：20
|
作者：
Majumdar, K. C. [1 ]
Mondal, Shovan [1 ]
机构：
[1] Univ Kalyani, Dept Chem, Kalyani 741235, W Bengal, India
来源：
TETRAHEDRON | 2009年 / 65卷 / 46期
关键词：
Uracil; Aza-Claisen rearrangement; Radical cyclization; 9-Deazaxanthines; 6-MEMBERED HETEROCYCLIC RINGS; AMINE OXIDE REARRANGEMENT; REGIOSELECTIVE SYNTHESIS; ANTIVIRAL ACTIVITY; CYTO-TOXICITY; PYRROLO<3,2-D>PYRIMIDINES; PYRIMIDINES; DERIVATIVES; HETEROANNULATION; SANGIVAMYCIN;
D O I：
10.1016/j.tet.2009.09.059
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new efficient route for the synthesis of substituted 9-deazaxanthines in excellent yields via aza-Claisen rearrangement followed by radical cyclization has been achieved. This methodology has also been applied to the synthesis of furo[3,2-d]pyrimidine. (C) 2009 Elsevier Ltd. All rights reserved
引用
收藏
页码：9604 / 9608
页数：5
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