Molecularly Imprinted Solid-Phase Extraction of 1-Methyl-2-piperidinoethylesters of Alkoxyphenylcarbamic Acid from Human Plasma, Comparison with Classical Solid-Phase Extraction

被引：1
|
作者：
Lachova, M. [1 ]
Lehotay, J. [1 ]
Skacani, I. [1 ]
Cizmarik, J. [2 ]
机构：
[1] Slovak Tech Univ Bratislava, Fac Chem & Food Technol, Inst Analyt Chem, Bratislava 81237, Slovakia
[2] Comenius Univ, Fac Pharm, Dept Pharmaceut Chem, Bratislava, Slovakia
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2009年 / 32卷 / 16期
关键词：
HPLC; Molecularly imprinted polymer; SPE; POLYMERS; SAMPLES; RECOGNITION; SEPARATION; POROGEN;
D O I：
10.1080/10826070903187684
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Molecularly imprinted polymers for 1-methyl-2-piperidinoethylester of 2-methoxyphenylcarbamic acid (template) have been synthesised using a non-covalent imprinting approach. Acrylamid and methacrylic acid, respectively, were used as the functional monomers. Imprinted polymers were used as the sorbents for solid-phase extraction (MISPE). The capacity and selectivity of prepared imprinted polymers was investigated. The non-imprinted (blank) polymers were prepared by the same way without template to study the non-specific interactions. Molecularly imprinted polymer prepared from methacrylic acid was used to preconcentrate 1-methyl-2-piperidinoethylester of 2-methoxyphenylcarbamic acid and its analogues from spiked human plasma.
引用
收藏
页码：2293 / 2306
页数：14
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