Enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers

被引：159
|
作者：
Belanger, Etienne [1 ]
Cantin, Katy [1 ]
Messe, Olivier [1 ]
Tremblay, Melanie [1 ]
Paquin, Jean-Francois [1 ]
机构：
[1] Univ Laval, Canada Res Chair Organ & Med Chem, Dept Chim, Quebec City, PQ G1K 7P4, Canada
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 05期
关键词：
D O I：
10.1021/ja067501q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers is reported. This reaction provides a stereoselective and efficient approach to allylated tertiary -fluoroketones from achiral fluorinated precursors. A variety of cyclic silyl enol ether can be used, and the yields of the desired products range from 52 to 93%, and the enantiomeric excesses range from 83 to 95% ee.
引用
收藏
页码：1034 / 1035
页数：2
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