A preliminary randomized controlled trial of contingency management for alcohol use reduction using a transdermal alcohol sensor

被引:73
|
作者
Barnett, Nancy P. [1 ]
Celio, Mark A. [1 ]
Tidey, Jennifer W. [1 ]
Murphy, James G. [2 ]
Colby, Suzanne M. [1 ]
Swift, Robert M. [1 ,3 ]
机构
[1] Brown Univ, Ctr Alcohol & Addict Studies, Box G-S121-5, Providence, RI 02912 USA
[2] Univ Memphis, Dept Psychol, Memphis, TN 38152 USA
[3] VA Med Ctr, Providence, RI USA
关键词
Alcohol; biosensor; contingency management; monitoring; reinforcement; transdermal; SUBSTANCE USE DISORDERS; VOUCHER-BASED REINFORCEMENT; ETHYL SULFATE ASSAYS; CLINICAL-TRIALS; AT-RISK DRINKING; ABUSE TREATMENT; DRUG-ABUSE; BLIND DECONVOLUTION; BREATH ALCOHOL; CIWA-AR;
D O I
10.1111/add.13767
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
AimsWe tested the efficacy of daily contingent reinforcement for reducing alcohol use compared with (yoked) non-contingent reinforcement (NR) using a transdermal alcohol sensor to detect alcohol use. DesignPilot randomized controlled design with 1 baseline week, 3 intervention weeks and 1-month follow-up. SettingNew England, USA. ParticipantsHeavy drinking adults (46.7% female) not seeking treatment were randomized to (1) an escalating schedule of cash reinforcement (CR; n=15) for days on which alcohol was neither reported nor detected or (2) yoked NR (n=15). Intervention and comparatorReinforcement for CR participants started at $5 and increased $2 every subsequent day on which alcohol was not detected or reported, to a maximum of $17. Participants received no reinforcement for days on which alcohol use was detected or reported, and the reinforcer value was re-set to $5 the day after a drinking day. NR participants were yoked to the daily reinforcer value of an individual in the CR condition, in order of enrollment. Paired participants in CR and NR therefore received the same amount of money, but the amount for the NR participant was not behavior-related. MeasurementsThe primary outcome was percentage of days without sensor-detected drinking. Secondary outcomes were number of consecutive days with no detected drinking, peak transdermal alcohol concentration (TAC), self-reported drinks per week and drinking below NIH low-risk guidelines. FindingsControlling for baseline, CR had a higher percentage of days with no drinking detected (54.3%) than NR (31.2%) during intervention weeks [P=0.05, Cohen's d=0.74; 95% confidence interval (CI)=0.007-1.47]. The longest period of consecutive days with no drinking detected was 8.0 for CR versus 2.9 for NR (P=0.03, d=0.85; 95% CI=0.08-1.61). Peak TAC during intervention showed a non-significant group difference (P=0.20; d=0.48; 95% CI=0.00-1.18); a similar result was found for drinks per week (P=0.12; d=0.59; 95% CI=0.00-1.30). Four times more participants in CR drank below NIH low-risk drinking guidelines during intervention than did participants in NR: 31.1 versus 7.1% (P=0.07; d=0.71; 95% CI=-0.04 to 1.46). At 1-month follow-up, the highest number of consecutive days without drinking (self-report) did not differ significantly between conditions (P=0.26), but showed a medium effect size (d=0.44; 95% CI=-0.32 to 1.18). ConclusionsCash incentives linked to a transdermal alcohol sensor can reduce heavy alcohol consumption while the incentives are in operation.
引用
收藏
页码:1025 / 1035
页数:11
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