A combined measles, mumps, rubella and varicella vaccine (Priorix-Tetra™): Immunogenicity and safety profile

被引：50
|
作者：
Hanna, Czajka [1 ]
Volker, Schuster [2 ]
Fred, Zepp [3 ]
Susanna, Esposito [4 ]
Martine, Douha [4 ]
Paul, Willems [5 ]
机构：
[1] Szpital Sw Ludwika, Vaccinat Outpatient Clin, PL-31503 Krakow, Poland
[2] Univ Leipzig, Hosp Children & Adolescents, D-04103 Leipzig, Germany
[3] Johannes Gutenberg Univ Mainz, Univ Hosp, Dept Pediat, D-55131 Mainz, Germany
[4] Univ Milan, Inst Pediat, Fdn IRCCS Osped Maggiore Policlin Mangiagalli & R, Milan, Italy
[5] GlaxoSmithKline Biol, Rixensart, Belgium
来源：
VACCINE | 2009年 / 27卷 / 47期
关键词：
Combined MMRV vaccine; Immunogenicity; Reactogenicity; ASEPTIC-MENINGITIS; HEALTHY-CHILDREN; REACTOGENICITY; PREVENTION; DECLINE; EUROPE; MMR;
D O I：
10.1016/j.vaccine.2009.07.076
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Priorix-Tetra (TM) (GlaxoSmithKline Biologicals) is a combined measles, mumps, rubella and varicella (MMRV) vaccine. Eight studies involving more than 3000 children were reviewed. Compared with co-administration of MMR (Priorix (TM)) and varicella (Varilrix (TM)) vaccines, the MMRV vaccine showed: similar immunogenicity, with immunity shown up to 3 years post-vaccination; a higher rate of fever after the first dose; a slight increase in mild local reactions after the second dose. This MMRV vaccine can be used either as a two-dose vaccine or as a second dose in children primed with separate MMR and/or varicella vaccines. offering a convenient way to introduce varicella vaccination into routine vaccination programmes. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6504 / 6511
页数：8
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