Global trends in antimicrobial resistance in animals in low- and middle-income countries

被引：630
|
作者：
Van Boeckel, Thomas P. [1 ,2 ,6 ]
Pires, Joao [1 ,6 ]
Silvester, Reshma [2 ]
Zhao, Cheng [1 ]
Song, Julia [3 ,4 ]
Criscuolo, Nicola G. [1 ]
Gilbert, Marius [5 ]
Bonhoeffer, Sebastian [6 ]
Laxminarayan, Ramanan [1 ,2 ,4 ]
机构：
[1] Swiss Fed Inst Technol, Inst Environm Decis, Zurich, Switzerland
[2] Ctr Dis Dynam Econ & Policy, New Delhi, India
[3] Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA
[4] Princeton Univ, Princeton Environm Inst, Princeton, NJ USA
[5] ULB, Brussels, Belgium
[6] Swiss Fed Inst Technol, Inst Integrat Biol, Zurich, Switzerland
来源：
SCIENCE | 2019年 / 365卷 / 6459期
基金：
瑞士国家科学基金会;
关键词：
ANTIBIOTIC-RESISTANCE; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; FOOD-ANIMALS; VALIDATION; TIME;
D O I：
10.1126/science.aaw1944
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The global scale-up in demand for animal protein is the most notable dietary trend of our time. Antimicrobial consumption in animals is threefold that of humans and has enabled large-scale animal protein production. The consequences for the development of antimicrobial resistance in animals have received comparatively less attention than in humans. We analyzed 901 point prevalence surveys of pathogens in developing countries to map resistance in animals. China and India represented the largest hotspots of resistance, with new hotspots emerging in Brazil and Kenya. From 2000 to 2018, the proportion of antimicrobials showing resistance above 50% increased from 0.15 to 0.41 in chickens and from 0.13 to 0.34 in pigs. Escalating resistance in animals is anticipated to have important consequences for animal health and, eventually, for human health.
引用
收藏
页码：1266 / +
页数：46
相关论文
共 50 条
  • [1] Global trends in antimicrobial resistance in animals in low- and middle-income countries
    van Boeckel, T.
    Pires, J.
    Silvester, R.
    Zhao, C.
    Song, J.
    Criscuolo, N.
    Gilbert, M.
    Bonhoeffer, S.
    Laxminarayan, R.
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 101 : 19 - 19
  • [2] Antimicrobial Resistance in Low- and Middle-income Countries
    Chopra, Sidharth
    Rizvi, Meher
    [J]. CLINICAL INFECTIOUS DISEASES, 2019, 69 (07) : 1264 - 1265
  • [3] Antimicrobial Resistance in Low- and Middle-income Countries Reply
    Gandra, Sumanth
    Arora, Anita
    Laxminarayan, Ramanan
    Klein, Eili Y.
    [J]. CLINICAL INFECTIOUS DISEASES, 2019, 69 (07) : 1265 - 1266
  • [4] Global Antimicrobial Stewardship with a Focus on Low- and Middle-Income Countries
    Pierce, Jacob
    Apisarnthanarak, Anucha
    Schellack, Natalie
    Cornistein, Wanda
    Al Maani, Amal
    Adnan, Syamhanin
    Stevens, Michael P.
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 96 : 621 - 629
  • [5] A Global Antimicrobial Conservation Fund for Low- and Middle-Income Countries
    Mendelson, Marc
    Dar, Osman A.
    Hoffman, Steven J.
    Laxminarayan, Ramanan
    Mpundu, Mirfin M.
    Rottingen, John-Arne
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2016, 51 : 70 - 72
  • [6] Factors driving antimicrobial resistance in low- and middle-income countries
    Laxminarayan, R.
    [J]. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2014, 21 : 52 - 52
  • [7] Antimicrobial Stewardship in Low- and Middle-Income Countries
    Dapas, Juan Ignacio
    Quiros, Rodolfo E.
    [J]. CURRENT TREATMENT OPTIONS IN INFECTIOUS DISEASES, 2018, 10 (01) : 17 - 27
  • [8] Antimicrobial Stewardship in Low- and Middle-Income Countries
    Juan Ignacio Dapás
    Rodolfo E. Quirós
    [J]. Current Treatment Options in Infectious Diseases, 2018, 10 (1) : 17 - 27
  • [9] Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture
    Iskandar, Katia
    Molinier, Laurent
    Hallit, Souheil
    Sartelli, Massimo
    Hardcastle, Timothy Craig
    Haque, Mainul
    Lugova, Halyna
    Dhingra, Sameer
    Sharma, Paras
    Islam, Salequl
    Mohammed, Irfan
    Naina Mohamed, Isa
    Hanna, Pierre Abi
    Hajj, Said El
    Jamaluddin, Nurul Adilla Hayat
    Salameh, Pascale
    Roques, Christine
    [J]. ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, 2021, 10 (01)
  • [10] Surveillance of antimicrobial resistance in low- and middle-income countries: a scattered picture
    Katia Iskandar
    Laurent Molinier
    Souheil Hallit
    Massimo Sartelli
    Timothy Craig Hardcastle
    Mainul Haque
    Halyna Lugova
    Sameer Dhingra
    Paras Sharma
    Salequl Islam
    Irfan Mohammed
    Isa Naina Mohamed
    Pierre Abi Hanna
    Said El Hajj
    Nurul Adilla Hayat Jamaluddin
    Pascale Salameh
    Christine Roques
    [J]. Antimicrobial Resistance & Infection Control, 10
12345