Self-assembly and function of primitive cell membranes

被引:72
|
作者
Pohorille, Andrew [1 ,2 ]
Deamer, David [3 ]
机构
[1] NASA, Ames Res Ctr, Exobiol Branch, Moffett Field, CA 94035 USA
[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA
[3] Univ Calif Santa Cruz, Dept Chem, Santa Cruz, CA 95064 USA
关键词
Origins of cellular life; Amphiphile self-assembly; Membrane permeability; Origin of ion channels; LIPID BILAYER-MEMBRANES; INFLUENZA-VIRUS; HYDROTHERMAL CONDITIONS; PHOSPHOLIPID-BILAYERS; AMPHIPATHIC PEPTIDES; TRANSMEMBRANE DOMAIN; PROTON CONDUCTION; ION-CHANNEL; M2; PROTEIN; RNA WORLD;
D O I
10.1016/j.resmic.2009.06.004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We describe possible pathways for separating amphiphilic molecules from organic material on the early earth to form membrane-bound structures required for the start of cellular life. We review properties of the first membranes and their function as permeability barriers. Finally, we discuss the emergence of protein-mediated ion transport across membranes, which facilitated many other cellular functions. (C) 2009 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:449 / 456
页数:8
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