INCORPORATION OF ACTIVE COMPOUNDS FROM MANGO PEEL (Mangifera indica L. Cv. "Tommy Atkins") INTO CORN STARCH-BASED ORAL DISINTEGRATING FILMS

This study aimed to evaluate the incorporation of mango peel extract, as a source of natural active compounds, in oral disintegrating films (ODF). The starch-based ODF were produced using a casting technique with glycerol as a plasticizer. Four formulations were tested by varying the amount of extract in the films: control, ODF 20, ODF 40, and ODF 60 (0, 20, 40, and 60 g of extract per 100 g of film0genic solution, respectively). The surface pH, disintegration time, total phenolic content, antioxidant activity, release of total phenolic content, and stability of the ODF was evaluated. All formulations studied could be classified as fast disintegrating films and source of phenolic compounds. ODF 60 showed the largest, most stable release of phenolic compounds under accelerated conditions (40 degrees C and 75% relative humidity). Thus, corn starch-based oral disintegrating films containing mango peel extract represent a useful vehicle for the delivery of phenolic compounds in the oral cavity.