Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver

被引：5
|
作者：
Takeichi, Takayuki [1 ,2 ,4 ]
Uemoto, Shinji [2 ]
Minamiguchi, Sachiko [3 ]
Takeyoshi, Izumi [4 ]
Inomata, Yukihiro [1 ]
Tanaka, Koichi [2 ]
Kobayashi, Eiji [5 ]
机构：
[1] Kumamoto Univ, Dept Transplantat & Pediat Surg, Postgrad Sch Med Sci, Kumamoto 8608556, Japan
[2] Kyoto Univ Hosp, Dept Transplantat & Immunol, Sakyo Ku, Kyoto 6068507, Japan
[3] Kyoto Univ Hosp, Anat Pathol Lab, Sakyo Ku, Kyoto 6068507, Japan
[4] Gunma Univ, Sch Med, Dept Surg 2, Gunma 3718511, Japan
[5] Jichi Med Sch, Ctr Mol Med, Div Organ Replacement Res, Minami Kawachi, Tochigi 3290498, Japan
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2009年 / 15卷 / 45期
关键词：
Ischemia-reperfusion injury; Leukotriene B(4); Liver; Tacrolimus; NEUTROPHIL INFILTRATION; SERUM CYTOKINES; LEUKOTRIENE B4; FK506; RAT; CYCLOSPORINE; PRETREATMENT; INHIBITOR;
D O I：
10.3748/wjg.15.5712
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AIM: To investigate the effects of a novel Leukotriene B(4) receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus.(1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more significantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreatment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver ischemia-reperfusion injury. (C) 2009 The WIG Press and Baishideng. All rights reserved.
引用
收藏
页码：5712 / 5715
页数：4
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