Study on the Strategy of Disinfectant Using in China's Space Station

Purpose Disinfectant is widely used in the International Space Station to help control the microbe level in the cabin environment. However, the long-term use of disinfectant with a single formula can generate microbial drug resistance and reduce the germicidal efficacy. Here, we try to find a method for the usage of disinfectant in China's future space station to prevent the resistance induction. Method We conducted the resistance induction experiment, using the minimum inhibitory concentration (MIC) as determinant to study the drug resistance of Candida albicans induced by compound disinfectants as well as disinfectants with a single formula. Conclusion Both the alternate use of disinfectants with different germicidal components and the use of compound disinfectant can effectively prevent or alleviate the induction of microbial drug resistance.