Structures of Kinesin Motor Proteins

被引：58

作者：

Marx, Alexander ^{[1
]}

Hoenger, Andreas ^{[2
]}

Mandelkow, Eckhard ^{[1
]}

机构：

[1] DESY, Max Planck Unit Struct Mol Biol, D-22607 Hamburg, Germany

[2] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA

来源：

CELL MOTILITY AND THE CYTOSKELETON | 2009年 / 66卷 / 11期

关键词：

kinesin; motor protein; microtubules; cytoskeleton; X-ray crystallography; cryoelectron microscopy; image reconstruction; X-RAY-STRUCTURE; CENTROMERE-ASSOCIATED KINESIN; STIMULATED ATP HYDROLYSIS; HAND-OVER-HAND; CRYSTAL-STRUCTURE; DIMERIC KINESIN; MICROTUBULE DEPOLYMERIZATION; CONFORMATIONAL-CHANGES; AXONAL-TRANSPORT; DRIVES MOTILITY;

D O I：

10.1002/cm.20392

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Almost 25 years of kinesin research have led to the accumulation of a large body of knowledge about this widespread superfamily of motor and nonmotor proteins present in all eukaryotic cells. This review covers developments in kinesin research with an emphasis on structural aspects obtained by X-ray crystallography and cryoelectron microscopy 3-D analysis on kinesin motor domains complexed to microtubules. Cell Motil. Cytoskeleton 66: 958-966, 2009. (C) 2009 Wiley-Liss, Inc.

引用

页码：958 / 966

页数：9

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