Morbidity, mortality and spatial distribution of meningococcal disease, 1974-2007

被引:24
|
作者
Howitz, M. [1 ]
Lambertsen, L. [2 ]
Simonsen, J. B. [3 ]
Christensen, J. J. [2 ]
Molbak, K. [1 ]
机构
[1] Statens Serum Inst, Dept Epidemiol, DK-2300 Copenhagen, Denmark
[2] Statens Serum Inst, Neisseria Streptococcus Reference Lab, DK-2300 Copenhagen, Denmark
[3] Statens Serum Inst, Dept Epidemiol Res, DK-2300 Copenhagen, Denmark
来源
EPIDEMIOLOGY AND INFECTION | 2009年 / 137卷 / 11期
关键词
Denmark; meningococcal disease; morbidity; mortality; Neisseria meningitidis; population density; serogroup; spatial distribution; CASE-FATALITY RATE; ANTIBIOTIC-TREATMENT; RISK-FACTOR; MENINGITIS; DENMARK; SURVEILLANCE; ASSOCIATION; CHILDREN; STRAINS; RATES;
D O I
10.1017/S0950268809002428
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
To identify determinants for mortality and sequelae and to analyse the spatial distribution of meningococcal disease, we linked four national Danish registries. In the period 1974-2007, 5924 cases of meningococcal disease were registered. Our analysis confirms known risk factors for a fatal meningococcal disease outcome, i.e. septicaemia and high age (> 50 years). The overall case-fatality rate was 7.6%; two phenotypes were found to be associated with increased risk of death; C:2a:P1.2,5 and B:15:P1.7,16. B:15:P1.7,16 was also associated with excess risk of perceptive hearing loss. The incidence rates of meningococcal disease were comparable between densely and less densely populated areas, but patients living further from a hospital were at significantly higher risk of dying from the infection. To improve control of meningococcal disease, it is important to understand the epidemiology and pathogenicity of virulent 'successful clones', such as C:2a:P1.2,5 and B:15:P1.7,16, and, eventually, to develop vaccines against serogroup B.
引用
收藏
页码:1631 / 1640
页数:10
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