Glioblastoma Multiforme: An Overview of Emerging Therapeutic Targets

被引：209
|
作者：
Taylor, Olivia G. [1 ,2 ,3 ]
Brzozowski, Joshua S. [1 ,2 ,3 ]
Skelding, Kathryn A. [1 ,2 ,3 ]
机构：
[1] Univ Newcastle, Prior Res Ctr Canc Res Innovat & Translat, Sch Biomed Sci & Pharm, Fac Hlth & Med, Callaghan, NSW, Australia
[2] Hunter Med Res Inst, Hunter Canc Res Alliance, New Lambton Hts, NSW, Australia
[3] Hunter Med Res Inst, Canc Res Program, New Lambton Hts, NSW, Australia
来源：
FRONTIERS IN ONCOLOGY | 2019年 / 9卷
关键词：
glioblastoma; targeted therapeutics; anti-cancer drugs; brain cancer; immunotherapy; ENDOTHELIAL GROWTH-FACTOR; TYROSINE KINASE INHIBITOR; PHASE-II TRIAL; C-MET; PROGNOSTIC-SIGNIFICANCE; TUMOR-GROWTH; RADIATION-THERAPY; MALIGNANT GLIOMAS; TEMOZOLOMIDE; EXPRESSION;
D O I：
10.3389/fonc.2019.00963
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumour in humans and has a very poor prognosis. The existing treatments have had limited success in increasing overall survival. Thus, identifying and understanding the key molecule(s) responsible for the malignant phenotype of GBM will yield new potential therapeutic targets. The treatment of brain tumours faces unique challenges, including the presence of the blood brain barrier (BBB), which limits the concentration of drugs that can reach the site of the tumour. Nevertheless, several promising treatments have been shown to cross the BBB and have shown promising pre-clinical results. This review will outline the status of several of these promising targeted therapies.
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页数：11
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