Amyloid-beta peptide forms monomeric complexes with CuII and ZnII prior to aggregation

被引：84

作者：

Talmard, Christine

Guilloreau, Luc

Coppel, Yannick

Mazarguil, Honore

Faller, Peter

机构：

[1] Univ Toulouse 3, CNRS UPR 824, Lab Chim Coordinat, F-31077 Toulouse 04, France

[2] Inst Pharmacol & Biol Struct, F-31077 Toulouse 04, France

来源：

CHEMBIOCHEM | 2007年 / 8卷 / 02期

关键词：

aggregation; amyloid beta peptides; bioinorganic chemistry; copper; zinc;

D O I：

10.1002/cbic.200600319

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Figure Presented) Brief encounter. ZnII- and Cu II-induced aggregation of the peptide amyloid-β (Aβ) are considered to be involved in Alzheimer's disease. The present data indicate that ZnII and CuII transiently form a monomeric complex with Aβ40/ 42 before aggregation, which exhibits no further transiently stable intermediate up to ∼15-mer. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：163 / 165

页数：3

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