A novel therapeutic option in Cogan diseases?: TNF-α blockers

被引：39
|
作者：
Fricker, M.
Baumann, A.
Wermelinger, F.
Villiger, P. M.
Helbling, A. [1 ]
机构：
[1] Univ Hosp, Inselspital, Dept Rheumatol & Clin Immuol Allergol, CH-3010 Bern, Switzerland
[2] Univ Hosp, Inselspital, Dept ENT & Head & Neck Surg, CH-3010 Bern, Switzerland
来源：
RHEUMATOLOGY INTERNATIONAL | 2007年 / 27卷 / 05期
关键词：
Cogan's syndrome; disease relapse; TNF-alpha blocker; infliximab; remisson;
D O I：
10.1007/s00296-006-0252-y
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cogan's syndrome is characterized by non-infectious, interstitial keratitis combined with a vestibulo-auditory deficit. Despite therapy with corticosteroids in combination with immunosuppressive agents, relapses occurred in two subjects and the clinical course suggested a progression of the disease. Treatment with anti-TNF-alpha was started leading to a rapid and sustained clinical remission for over 2 respectively 3 years.
引用
收藏
页码：493 / 495
页数：3
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