Analysis of Spontaneous EEG Activity in Alzheimer's Disease Patients by Means of Multiscale Spectral Entropy

被引：2

作者：

Maturana-Candelas, A. ^{[1
]}

Gomez, C. ^{[1
]}

Poza, J. ^{[1
,2
]}

Ruiz-Gomez, S. J. ^{[1
]}

Nunez, P. ^{[1
]}

Rodriguez, M. ^{[3
]}

Figueruelo, M. ^{[3
]}

Pita, C. ^{[3
]}

Pinto, N. ^{[4
,5
]}

Martins, S. ^{[4
]}

Lopes, A. M. ^{[4
]}

Gomes, I ^{[4
]}

Hornero, R. ^{[1
,2
]}

机构：

[1] Univ Valladolid, Biomed Engn Grp, Valladolid, Spain

[2] Univ Valladolid, Inst Invest Matemat, Valladolid, Spain

[3] Assoc Familiares & Amigos Enfermos Alzheimer & Ot, Zamora, Spain

[4] Univ Porto, Inst Patol & Imunol Mol, Porto, Portugal

[5] Univ Porto, Ctr Matemat, Porto, Portugal

来源：

CONVERGING CLINICAL AND ENGINEERING RESEARCH ON NEUROREHABILITATION III | 2019年 / 21卷

关键词：

D O I：

10.1007/978-3-030-01845-0_116

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The aim of this study was to analyze electroencephalographic (EEG) background activity in Alzheimer's disease (AD) and mild cognitive impairment (MCI) by means of multiscale spectral entropy (MSSE). To achieve this goal, five minutes of EEG activity were acquired from 18 cognitive healthy controls, 10 MCI subjects and 32 AD patients. Our results showed statistically significant differences (p-values < 0.05, Kruskal-Wallis test) in MSSE values for all scale factors. Additionally, a 3D receiver operating characteristic (ROC) curve was used to assess the discrimination ability of MSSE among the 3 groups, showing a good three-way discrimination power (volume under the surface of 0.6). These results suggest that MSSE can be a useful measure to characterize neural alterations in AD, even at early stages.

引用

页码：579 / 583

页数：5

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