Treating infants with neonatal abstinence syndrome: an examination of three protocols

被引:3
|
作者
Hartgrove, Morgan J. [1 ]
Meschke, Laurie L. [2 ]
King, Terry L. [3 ]
Saunders, Carla [4 ,5 ]
机构
[1] Univ Tennessee, Knoxville, TN 37996 USA
[2] Univ Tennessee, Dept Publ Hlth, Knoxville, TN 37996 USA
[3] East Tennessee Childrens Hosp, Clin Pharm, Knoxville, TN 37916 USA
[4] Pediat Med Grp, Knoxville, TN 37916 USA
[5] East TN Childrens Hosp, Knoxville, TN 37916 USA
关键词
UNITED-STATES; INCREASING INCIDENCE; PERINATAL OUTCOMES; METHADONE; PRETERM; TERM; HOSPITALS; PREGNANCY; MOTHERS;
D O I
10.1038/s41372-019-0450-6
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective Describe the characteristics of infants with NAS and determine if treatment outcomes varied between three protocols. Study design Based on medical record data, infant treatment for NAS-related withdrawal reflected one of three protocols: (1) No rescue dose (n = 836, 52.7%): Prescriber ordered initiation and escalation doses and determined when infants were eligible for weaning, (2) Rescue dose (n = 233, 14.7%): No rescue dose with the addition of a prescriber-ordered rescue dose, (3) Rescue dose by order set (n = 516, 32.6%): Rescue dose with addition of nurse-assisted order of morphine during escalation. Results The no rescue dose group had longer length of stay, days to wean, and inpatient days, and greater initial morphine dose than the two rescue dose groups (p < 0.001). Treatment outcomes between the two rescue dose protocols did not differ. Conclusions The benefits related to rescue dosing further inform the development of a standardized NAS treatment protocol.
引用
收藏
页码:1377 / 1383
页数:7
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