Application of Raman spectra in solid-phase organic synthesis

The recent application of Raman spectroscopy in solid-phase organic synthesis is reviewed. Two Raman spectra techniques of NIR-FT-Raman spectroscopy and confocal Raman microscopy are introduced respectively. NIR-FT-Raman spectroscopy can be used for the characterization of solid-supported reagents and catalysts, for monitoring the solid-phase reactions, and especially for monitoring the solid-phase reactions on inorganic supports since the interference of fluorescence emission background can be removed by this technique. Confocal Raman microscopy is used to study the distribution of reactive sites within a resin bead and characterize the structure of grafted supports. used for solid-phase synthesis taking the advantage of its high spatial resolution.