Simulation is a key technology for Industry 4.0 which helps achieving several of Industry 4.0 use cases like flexible production or product design. However, simulating complex industrial systems with several modules and sub-systems is a complicated task which includes co-operation and orchestration of separated simulation models. Therefore, this work proposes a solution that enables simulation interoperability and orchestration using Asset Administration Shell (AAS)-based semantic descriptions. The proposed approach is also verified via a real scenario that enables dimensioning of drives in a drive-train while controlling the holistic simulation.