Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases

被引：52

作者：

Gerdes, Erin O. Wissler ^{[1
]}

Zhu, Yi ^{[1
]}

Weigand, B. Melanie ^{[1
]}

Tripathi, Utkarsh ^{[1
]}

Burns, Terence C. ^{[1
]}

Tchkonia, Tamar ^{[1
]}

Kirkland, James L. ^{[1
]}

机构：

[1] Mayo Clin, Robert & Arlene Kogod Ctr Aging, Rochester, MN 55905 USA

来源：

METABOLIC AND BIOENERGETIC DRIVERS OF NEURODEGENERATIVE DISEASE: TREATING NEURODEGENERATIVE DISEASES AS METABOLIC DISEASES | 2020年 / 155卷

关键词：

MILD COGNITIVE IMPAIRMENT; SECRETORY PHENOTYPE; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; HIPPOCAMPAL NEUROGENESIS; RADIATION-RESISTANCE; SUBSTANTIA-NIGRA; UNITED-STATES; WHITE-MATTER; BRAIN;

D O I：

10.1016/bs.irn.2020.03.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aging is the major predictor for developing multiple neurodegenerative diseases, including Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells, which can drive aging phenotypes, accumulate at etiological sites of many age-related chronic diseases. These cells are resistant to apoptosis and can cause local and systemic dysfunction. Decreasing senescent cell abundance using senolytic drugs, agents that selectively target these cells, alleviates neurodegenerative diseases in preclinical models. In this review, we consider roles of senescent cells in neurodegenerative diseases and potential implications of senolytic agents as an innovative treatment.

引用

页码：203 / 234

页数：32

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