Integrated measurement system for simultaneous functional magnetic resonance imaging and diffuse optical tomography in human brain mapping

被引:8
|
作者
Zhang, Xiaofeng
Toronov, Vladislav Y.
Webb, Andrew G. [1 ]
机构
[1] Penn State Univ, Dept Bioengn, University Pk, PA 16802 USA
[2] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA
来源
REVIEW OF SCIENTIFIC INSTRUMENTS | 2006年 / 77卷 / 11期
关键词
D O I
10.1063/1.2364138
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
An integrated measurement system has been developed for performing simultaneous functional magnetic resonance imaging (fMRI) and diffuse optical tomography (DOT) for human brain mapping experiments. The components of this system consist of a MRI-compatible multioverlapping-channel near-infrared (NIR) optical probe, techniques for accurate and reliable coregistration of optical and fMRI results, and an optical image reconstruction algorithm with structural and physiological constraints derived from the MRI data. The optical probe is fully MRI compatible in that it produces negligible MR image distortion and does not require any modification to the MRI scanner or data acquisition protocols. This probe can be attached to virtually any part of the head without imposing limits on optical data acquisition. Coregistration of images from fMRI and optical measurements is achieved by localizing the positions of the optical fibers using MRI markers. Human studies show successful implementation of the entire system.
引用
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页数:8
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