Leukotriene A4 hydrolase

被引：36
|
作者：
Haeggström, JZ [1 ]
Kull, F
Rudberg, PC
Tholander, F
Thunnissen, MMGM
机构：
[1] Karolinska Inst, Dept Med Biochem & Biophys, Div Chem 2, S-17177 Stockholm, Sweden
[2] Univ Stockholm, Arrhenius Labs A4, Dept Biochem, S-10691 Stockholm, Sweden
来源：
PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2002年 / 68-9卷
关键词：
leukotriene; aminopeptidase; inflammation; crystal structure; epoxide hydrolase;
D O I：
10.1016/S0090-6980(02)00051-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The leukotrienes (LTs) are a family of lipid mediators involved in inflammation and allergy. Leukotriene B-4 is a classical chemoattractant, which triggers adherence and aggregation of leukocytes to the endothelium at only nanomolar concentrations. In addition, leukotriene B4 modulates immune responses, participates in the host-defense against infections, and is a key mediator of PAF-induced lethal shock. Because of these powerful biological effects, leukotriene B4 is implicated in a variety of acute and chronic inflammatory diseases, e.g. nephritis, arthritis, dermatitis, and chronic obstructive pulmonary disease. The final step in the biosynthesis of leukotriene B-4 is catalyzed by leukotriene A(4) hydrolase, a unique bi-functional zinc metalloenzyme with an anion-dependent aminopeptidase activity. Here we describe the most recent developments regarding our understanding of the structure, function, and catalytic mechanisms of leukotriene A4 hydrolase. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：495 / 510
页数：16
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