Fractional exhaled nitric oxide in asthma: an update

被引：61

作者：

Sandrini, Alessandra ^{[1
]}

Taylor, D. Robin ^{[5
]}

Thomas, Paul S. ^{[2
,3
,4
]}

Yates, Deborah H. ^{[1
]}

机构：

[1] Univ New S Wales, Dept Thorac Med, St Vincents Hosp, Sydney, NSW 2010, Australia

[2] Univ New S Wales, Sch Med Sci, Ctr Infect & Inflammat Res, Sydney, NSW 2010, Australia

[3] Univ New S Wales, Fac Med, Prince Wales Clin Sch, Sydney, NSW 2010, Australia

[4] Prince Wales Hosp, Dept Resp Med, Randwick, NSW 2031, Australia

[5] Univ Otago, Dunedin Sch Med, Dept Med, Dunedin, New Zealand

来源：

RESPIROLOGY | 2010年 / 15卷 / 01期

关键词：

airway inflammation; asthma; eosinophilic inflammation; eosinophil; inhaled steroid; non-invasive monitoring; OBSTRUCTIVE PULMONARY-DISEASE; SPUTUM EOSINOPHIL COUNTS; AIR-FLOW OBSTRUCTION; HAND-HELD DEVICE; MILD ASTHMA; BRONCHOALVEOLAR LAVAGE; INHALED BECLOMETHASONE; CLINICAL REMISSION; BREATH CONDENSATE; DIFFICULT ASTHMA;

D O I：

10.1111/j.1440-1843.2009.01616.x

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In asthma, clinical symptoms and lung function are insensitive in reflecting the underlying airway inflammation, and monitoring of this process has only recently become available. Fractional exhaled nitric oxide (Fe-NO) is now recognized as a reliable surrogate marker of eosinophilic airway inflammation and offers the advantage of being completely non-invasive and very easy to obtain. This review summarizes the clinical use of Fe-NO in asthma. It covers the relationship between Fe-NO and the underlying eosinophilic inflammation, the pathophysiology and production of Fe-NO, technical aspects of Fe-NO measurement and potential confounding factors in interpreting levels. Fe-NO reference values and the role of Fe-NO in asthma assessment, diagnosis and management are also discussed.

引用

页码：57 / 70

页数：14

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