Changes in brain oxidative metabolism induced by water maze training

被引：35
|
作者：
Conejo, N. M.
Gonzalez-Pardo, H.
Vallejo, G.
Arias, J. L.
机构：
[1] Univ Oviedo, Fac Psychol, Lab Neurosci, E-33003 Oviedo, Spain
[2] Univ Oviedo, Fac Psychol, Methodol Area, E-33003 Oviedo, Spain
来源：
NEUROSCIENCE | 2007年 / 145卷 / 02期
关键词：
limbic system; spatial memory; oxidative metabolism; rat;
D O I：
10.1016/j.neuroscience.2006.11.057
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Although the hippocampus has been shown to be essential for spatial memory, the contribution of associated brain regions is not well established. Wistar rats were trained to find a hidden escape platform in the water maze during eight days. Following training, the oxidative metabolism in different brain regions was evaluated using cytochrome oxidase histochemistry. Metabolic activations were found in the prelimbic cortex, cornu ammonis (CA) 1 subfield of the dorsal hippocampus and the anterior thalamic nuclei, relative to yoked swim controls and naive rats. In addition, many cross-correlations in brain metabolism were observed among the latter regions. These results support the implication of a hippocampal-prefrontal-thalamic system to spatial memory in rats. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：403 / 412
页数：10
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