Sinulobatins A similar to D, new amphilectane-type diterpenoids from the Japanese soft coral Sinularia nanolobata

被引：24

作者：

Yamada, K ^{[1
]}

Ujiie, T ^{[1
]}

Yoshida, K ^{[1
]}

Miyamoto, T ^{[1
]}

Higuchi, R ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC PHARMACEUT SCI,HIGASHI KU,FUKUOKA 81282,JAPAN

来源：

TETRAHEDRON | 1997年 / 53卷 / 13期

关键词：

D O I：

10.1016/S0040-4020(97)00169-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new amphilectane-type diterpenoids, sinulobatins A (1), B (2), C(3) and D (4) were isolated from the Japanese soft coral Sinularia nanolobata. Their determined based on spectroscopic evidence and single crystal X-ray analysis. The absolute stereochemistry of 1 was elucidated on the basis of its CD spectrum. These compounds exhibited cytotoxicity against L1210 cells and KB cells in vitro with IC50 values of 3.0 - 7.7 mu g/mL. (C) 1997 Elsevier Science Ltd.

引用

页码：4569 / 4578

页数：10

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