The Ebolavirus VP24 Protein Blocks Phosphorylation of p38 Mitogen-Activated Protein Kinase

被引：35
|
作者：
Halfmann, Peter [1 ]
Neumann, Gabriele [1 ]
Kawaoka, Yoshihiro [1 ,2 ,3 ,4 ]
机构：
[1] Univ Wisconsin Madison, Influenza Res Inst, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53715 USA
[2] Univ Tokyo, Div Virol, Dept Microbiol & Immunol, Tokyo, Japan
[3] Univ Tokyo, Inst Med Sci, Int Res Ctr Infect Dis, Tokyo, Japan
[4] Japan Sci & Technol Agcy, ERATO Infect Induced Host Responses Project, Saitama, Japan
来源：
JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷
基金：
美国国家卫生研究院;
关键词：
VP35; PROTEIN; VIRUS; INTERFERONS; KARYOPHERIN; STAT1;
D O I：
10.1093/infdis/jir325
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type I interferon (IFN) signaling is mediated through several signaling pathways, including the Janus kinase and signal transducer and activator (JAK-STAT) and p38 mitogen-activated protein (MAP) kinase pathways. The VP24 protein of Ebolavirus is an IFN antagonist, blocking type I IFN signaling through the JAK-STAT pathway. Here, we show that, in 293 cells, VP24 also interferes with the p38 MAP kinase pathway by blocking IFN-beta-stimulated phosphorylation of p38-alpha. Similar inhibition was not observed in HeLa cells, suggesting cell type-specific differences in signal transduction.
引用
收藏
页码：S953 / S956
页数：4
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