Subthalamic Nucleus Deep Brain Stimulation Improves Saccades in Parkinson's Disease

被引:22
|
作者
Fawcett, Adrian P. [2 ]
Gonzalez, Esther G. [3 ,4 ]
Moro, Elena [5 ]
Steinbach, Martin J. [3 ,4 ]
Lozano, Andres M. [1 ]
Hutchison, William D. [1 ,2 ,3 ]
机构
[1] Toronto Western Hosp, Div Neurosurg, Dept Surg, Toronto, ON M5T 2S8, Canada
[2] Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5S 1A8, Canada
[3] Toronto Western Res Inst, Vis Sci Res Program, Toronto, ON, Canada
[4] Univ Toronto, Dept Ophthalmol, Toronto, ON M5S 1A1, Canada
[5] Toronto Western Hosp, Movement Disorders Ctr, Dept Neurol, Toronto, ON M5T 2S8, Canada
来源
NEUROMODULATION | 2010年 / 13卷 / 01期
基金
加拿大自然科学与工程研究理事会;
关键词
Basal ganglia; DBS; movement disorders; neurosurgery; ocular motor; HIGH-FREQUENCY STIMULATION; MEMORY-GUIDED SACCADES; BASAL GANGLIA; GLUCOSE-METABOLISM; EYE-MOVEMENT; CORTEX; MONKEY; VOLUNTARY; REFLEXIVE; DEFICITS;
D O I
10.1111/j.1525-1403.2009.00246.x
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objectives. The clinical efficacy of subthalamic nucleus (STN) deep brain stimulation (DBS) for major motor symptoms of Parkinson's disease (PD) is well established, but its effects on visually guided vs. internally generated eye movements in the medication off state need to be studied further. Since the basal ganglia are thought to be involved in the generation of voluntary movements under internal control, we hypothesized that voluntary saccades would show improvements with STN DBS. Materials and Methods. Seven PD patients with STN DBS performed visually guided and internally generated (anti- and memory-guided) saccades with STN DBS on and off following 12 hours of levodopa withdrawal. The change in saccade reaction time, first saccade gain, and final saccade gain with STN DBS were measured. Results. STN DBS improved the reaction time of visually guided saccades but not of anti- or memory-guided saccades. STN DBS also improved the first saccade gain of the anti- and memory-guided saccades, but not of the visually guided saccades. Conclusions. These results demonstrate that STN DBS has differential effects on the parameters of visually guided and internally generated saccades. These effects may be mediated by the influence of STN DBS on cortical ocular motor areas, the basal ganglia, ocular motor loop, or downstream structures such as the brainstem saccade generating circuits.
引用
收藏
页码:17 / 24
页数:8
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