Calcium mechanism of norepinephrine activation of ionic pump in somatic cells of Lumbricus terrestris earthworm muscle wall

被引:2
|
作者
Volkov, EM [1 ]
Nurullin, LF [1 ]
Obukhova, AS [1 ]
Chikin, AV [1 ]
Nikol'skii, EE [1 ]
机构
[1] Kazan State Med Univ, Kazan, Russia
关键词
norepinephrine; muscle cells; earthworm;
D O I
10.1023/A:1020688117507
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Blockade of norepinephrine-induced hyperpolarization in earthworm muscle cells was observed in a calcium-free medium, after substitution of Ca2+ with Mn2+, and in the presence of verapamil or chlorpromazine to the incubation saline. Changes in Ca2+ concentration in the saline and addition of caffeine had no effect on the resting potential of muscle cells. It was hypothesized that signal transduction from norepinephrine-activated membrane adrenoceptors to the ionic pump in earthworm muscle cells depends on influx of extracellular Ca2+ and subsequent involvement of Ca2+-accepting proteins similar to calmodulin in vertebrates.
引用
收藏
页码:18 / 19
页数:2
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