A model for sperm-egg binding and fusion based on ADAMs and integrins

被引：39
|
作者：
Bigler, D
Chen, M
Waters, S
White, JM
机构：
[1] University of Virginia, Dept. of Cell Biology, Health Sciences Center, Charlottesville
来源：
TRENDS IN CELL BIOLOGY | 1997年 / 7卷 / 06期
关键词：
D O I：
10.1016/S0962-8924(97)01058-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Once a sperm meets an egg, several events must occur in order for fertilization to proceed. Sperm must bind to the zona pellucida, undergo the acrosome reaction, penetrate the zona pellucida and then bind to and fuse with the egg plasma membrane. Shortly thereafter, the egg must be activated for zygotic development. This review focuses on mammalian sperm-egg plasma membrane binding and fusion, and in particular on the roles of two families of cell-adhesion molecules, ADAMs and integrins, in this important union.
引用
收藏
页码：220 / 225
页数：6
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