Sex-specific incidence rates and risk factors for fracture: A 16-year follow-up from the Tehran lipid and glucose study

被引:4
|
作者
Hadaegh, Farzad [1 ]
Asgari, Samaneh [1 ]
Toreyhi, Hossein [1 ]
Eskandari, Fatemeh [1 ]
Fahimfar, Noushin [4 ,5 ]
Bozorgmanesh, Mohammadreza [6 ]
Hosseinpanah, Farhad [2 ]
Azizi, Fereidoun [3 ]
机构
[1] Shahid Beheshti Univ Med Sci, Prevent Metab Disorders Res Ctr, Res Inst Endocrine Sci, POB 19395-4763, Tehran, Iran
[2] Shaheed Beheshti Univ Med Sci, Obes Res Ctr, Res Inst Endocrine Sci, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran
[4] Univ Tehran Med Sci, Osteoporosis Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran
[5] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran
[6] Arak Univ Med Sci, Dept Orthoped Surg, Arak, Iran
关键词
Fracture; Incident; Risk factor; TYPE-2; DIABETES-MELLITUS; BONE-MINERAL DENSITY; HIP FRACTURE; CARDIOVASCULAR OUTCOMES; WORLDWIDE PREVALENCE; EPIDEMIOLOGY; ASSOCIATION; OSTEOPOROSIS; METAANALYSIS; WOMEN;
D O I
10.1016/j.bone.2021.115869
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To examine the population-based incidence of any-fracture and its potential risk factors in a sex-split cohort of the Iranian population. Materials and methods: A total of 3477 men and 4085 women with a mean (SD) age of 47.92(13.1) and 45.88 (11.47) years, respectively were entered into the study. The age-standardized incidence rates per 100,000 person-years were reported for the whole population and each sex separately. Cox proportional hazard models were used to estimate hazard ratios (HR) for potential risk factors. Only fractures requiring inpatients? care were considered as the outcome. We also defined major osteoporotic fractures (MOF) as the composite of the fractures that occurred in the vertebral, wrist, hip and pelvic sites among population aged >50 years. Results: During the median (IQR) follow-up of 15.9 years, 4.34%men and 3.75% women experienced at least one incident any-fracture. The annual age-standardized incidence rates (95% CI) among men and women were 330.9 (279.6?388.9) and 319.4(268.1?377.3) per 100,000 person-years, respectively; the corresponding values for incidence of MOF was 202.2(142.3?278.6) in men and 342.1(260.4?441.0) per 100,000 person-years for women. In the multivariable model, among the whole population, age groups >50 years, central obesity [HR: 95% CI 1.77(1.32?2.39)], current smoking [1.59(1.15?2.20)] and using steroid medications [2.20(1.04?4.67)] significantly increased the risk of incident fracture (all P < 0.05); however the impact of the first two risk factors were more prominent among women (P for interaction ?0.01). Moreover, being obese was associated with a lower risk of incident first fracture in the total population [HR: 95% CI: 0.61(0.40?0.92)]. Being men [HR: 95% CI: 0.54 (0.30?0.99)] and prediabetes status [HR: 95% CI: 0.53(0.30-0.95)] were also associated with lower risk for MOF. Conclusion: This is the first report of long-term incidence rate of any-fracture and MOF conducted in the metropolitan city of Tehran. Among modifiable risk factors of fracture, in the whole population smoking habit and using steroid medications and particularly for women central obesity should be considered as main risk factors for preventive strategies. Prediabetes status was associated with lower risk of MOF.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Sex-Specific Incidence Rates and Risk Factors for Hypertension During 13 Years of Follow-up: The Tehran Lipid and Glucose Study
    Asgari, Samaneh
    Moazzeni, Seyyed Saeed
    Azizi, Fereidoun
    Abdi, Hengameh
    Khalili, Davood
    Hakemi, Monir Sadat
    Hadaegh, Farzad
    GLOBAL HEART, 2020, 15 (01)
  • [2] Sex-specific incidence rates and risk factors of premature cardiovascular disease. A long term follow up of the Tehran Lipid and Glucose Study
    Eslami, Ali
    Mozaffary, Amirhossein
    Derakhshan, Arash
    Azizi, Fereidoun
    Khalili, Davood
    Hadaegh, Farzad
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2017, 227 : 826 - 832
  • [3] Sex Specific Incidence Rates of Type 2 Diabetes and Its Risk Factors over 9 Years of Follow-Up: Tehran Lipid and Glucose Study
    Derakhshan, Arash
    Sardarinia, Mahsa
    Khalili, Davood
    Momenan, Amir Abbas
    Azizi, Fereidoun
    Hadaegh, Farzad
    PLOS ONE, 2014, 9 (07):
  • [4] Sex-specific clinical outcomes of impaired glucose status: A long follow-up from the Tehran Lipid and Glucose Study
    Parizadeh, Donna
    Rahimian, Neda
    Akbarpour, Samaneh
    Azizi, Fereidoun
    Hadaegh, Farzad
    EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2019, 26 (10) : 1080 - 1091
  • [5] Incidence and risk factors of isolated systolic and diastolic hypertension: a 10 year follow-up of the Tehran Lipids and Glucose Study
    Asgari, Samaneh
    Khalili, Davood
    Mehrabi, Yadollah
    Kazempour-Ardebili, Sara
    Azizi, Fereidoun
    Hadaegh, Farzad
    BLOOD PRESSURE, 2016, 25 (03) : 177 - 183
  • [6] Sex-specific incidence rates and risk factors of insulin resistance and -cell dysfunction: a decade follow-up in a Middle Eastern population
    Derakhshan, A.
    Tohidi, M.
    Hajebrahimi, M. A.
    Saadat, N.
    Azizi, F.
    Hadaegh, F.
    DIABETIC MEDICINE, 2017, 34 (02) : 245 - 252
  • [7] A cohort study on dementia and the risk of periodontitis over a 16-year follow-up
    Ma, K. Kai
    Veeravalli, J.
    Hasturk, H.
    Carreras, I.
    Dedeoglu, A.
    Kantarci, A.
    EUROPEAN JOURNAL OF NEUROLOGY, 2021, 28 : 339 - 339
  • [8] Cause-specific mortality by education in Canada: A 16-year follow-up study
    Tjepkema, Michael
    Wilkins, Russell
    Long, Andrea
    HEALTH REPORTS, 2012, 23 (03) : 23 - 31
  • [9] Prospective assessment of coronary heart disease risk factors: The NHANES I epidemiologic follow-up study (NHEFS) 16-year follow-up
    Gartside, PS
    Wang, P
    Glueck, CJ
    JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 1998, 17 (03) : 263 - 269
  • [10] Sex specific trajectories of central adiposity, lipid indices, and glucose level with incident hypertension: 12 years Follow-up in Tehran lipid and glucose study
    Ahanchi, Noushin Sadat
    Tamehri Zadeh, Seyed Saeed
    Khalili, Davood
    Azizi, Fereidoun
    Hadaegh, Farzad
    JOURNAL OF TRANSLATIONAL MEDICINE, 2021, 19 (01)