Rapid Antigen Diagnostics as Frontline Testing in the COVID-19 Pandemic

被引：11

作者：

Xu, Jiang ^{[1
,2
]}

Kerr, Liam ^{[3
]}

Jiang, Yue ^{[4
]}

Suo, Wenhao ^{[5
,6
]}

Zhang, Lei ^{[7
]}

Lao, Taotao ^{[8
,9
]}

Chen, Yuxin ^{[10
]}

Zhang, Yan ^{[11
,12
]}

机构：

[1] Harvard Med Sch, Blavatnik Inst, Dept Syst Biol, Boston, MA 02115 USA

[2] Virogin Biotech Ltd, Dept Mol Virol, 3800 Wesbrook Mall, Vancouver, BC V6S 2L9, Canada

[3] McGill Univ, Ctr Intelligent Machines, Dept Mech Engn, Montreal, PQ H3A 0C3, Canada

[4] Jiaxing Univ, China Australia Inst Adv Mat & Mfg, Jiaxing 314001, Peoples R China

[5] Harvard Med Sch, Dana Farber Canc Inst, Boston, MA 02215 USA

[6] Xiamen Univ, Affiliated Hosp 1, Dept Pathol, Xiamen 361003, Peoples R China

[7] Univ Waterloo, Waterloo Inst Nanotechnol, Dept Chem Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada

[8] Boston Mol Inc, Dept Mol Diagnost, 564 Main St, Waltham, MA 02452 USA

[9] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Charlestown, MA 02114 USA

[10] Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Dept Lab Med, Nanjing 210008, Jiangsu, Peoples R China

[11] Tianjin Univ, Sch Pharmaceut Sci & Technol, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Key Lab Modern Drug Delivery & HighEffici, Tianjin 300072, Peoples R China

[12] Tianjin Univ, Frontiers Sci Ctr Synthet Biol, Minist Educ, Tianjin, Peoples R China

来源：

SMALL SCIENCE | 2022年 / 2卷 / 08期

基金：

美国国家卫生研究院;

关键词：

antigentests; COVID-19; in vitro diagnostics; immnuoassay; ELISA; SARS-COV-2; ASSAY; BIOSENSORS; SYSTEM;

D O I：

10.1002/smsc.202200009

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The ongoing global COVID-19 pandemic, caused by the SARS-CoV-2 virus, has resulted in significant loss of life since December 2019. Timely and precise virus detection has been proven as an effective solution to reduce the spread of the virus and to track the epidemic. Rapid antigen diagnostics has played a significant role in the frontline of COVID-19 testing because of its convenience, low cost, and high accuracy. Herein, different types of recently innovated in-lab and commercial antigen diagnostic technologies with emphasis on the strengths and limitations of these technologies including the limit of detection, sensitivity, specificity, affordability, and usability are systematically reviewed. The perspectives of assay development are looked into.

引用

页数：14

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