Determination of paracetamol by flow injection chemiluminescence analysis

Paracetamol can greatly inhibit the emission intensity of the chemiluminescence reaction of K3Fe(CN)(6) and luminol in basic medium. Based on this phenomenon, a new method for the determination of paracetamol is developed coupling flow injection technique and the mechanism of the reaction is also discussed. The linear range is 4.0 x 10(-8) similar to 1.0 x 10(-6) g/mL with a detection limit of 2.4 x 10(-9) g/mL and the relative standard deviation is 2.3% (C = 8.0 x 10(-7) g/mL, n = 11). The method has been applied to the determination of paracetamol in tablets, and the results agree well with standard method.