Synthesis of novel biodegradable poly(ethylene glycol) analogue: Water-soluble aliphatic polyester with pendant oligo(ethylene glycol) chains

被引：2

作者：

Feng, Lei ^{[1
,3
]}

Hao, Jian Yuan ^{[1
,2
]}

Xiong, Cheng Dong ^{[1
]}

Deng, Xian Mo ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China

[2] Univ Elect Sci & Technol China, Sch Microeletron & Solid State Elect, Chengdu 610054, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2009年 / 20卷 / 12期

关键词：

Water-soluble; PEG analogue; 2-((2-(2-Methoxyethoxy)ethoxy)methyl)oxirane; Ring-opening alternating copolymerization; Polyester;

D O I：

10.1016/j.cclet.2009.06.013

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel poly(ethylene glycol) (PEG) analogue composed of aliphatic polyester backbone and pendant oligo(ethylene glycol) short chains is reported. The PEG analogue is a copolymer synthesized by ring-opening alternating copolymerization of succinic anhydride with 2-((2-(2-metho xyethoxy)ethoxy)methyl)oxirane. The structure of the copolymer was confirmed by H-1 NMR spectrum. The effects of the monomer feed ratio on the copolymerization were studied and the polymerization mechanism was given. The PEG analogue disclosed is water-soluble and expected to have promising applications in biomedical fields as a substitute of PEG due to the existence of degradable ester bond in the backbone. (C) 2009 Jian Yuan Hao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1502 / 1505

页数：4

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