Towards a genome-wide reconstruction of cis-regulatory networks in the human genome

被引：5

作者：

Cecchini, Katharine R. ^{[1
]}

Banerjee, A. Raja ^{[1
]}

Kim, Tae Hoon ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2009年 / 20卷 / 07期

关键词：

Chromatin structure; Cis-regulatory network; Enhancers; Silencers; Promoters; Insulators; Functional genomics; ChIP; BETA-GLOBIN LOCUS; PROTEIN-DNA INTERACTIONS; CONTROL REGION; HISTONE MODIFICATIONS; GENE-EXPRESSION; TRANSCRIPTIONAL PROMOTERS; HYPERSENSITIVE SITES; TARGETED DELETION; ENHANCER-BLOCKING; NUCLEAR LAMINA;

D O I：

10.1016/j.semcdb.2009.06.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The vast amount of recent progress made on the sequence of the human genome has allowed an unprecedented examination of cis-regulatory networks. These networks consist of functional elements such as promoters, enhancers, silencers, and insulators, and their coordinated activity is responsible for regulation of gene expression. Recent studies surveyed the entire genome, identifying novel elements and evaluating functional differences in respect to development. These investigations present the first steps towards a global regulatory map for expression in the human genome. (C) 2009 Published by Elsevier Ltd.

引用

页码：842 / 848

页数：7

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