Improved stereoselectivity in intramolecular SN2′ cyclization through use of mechanistic principles

被引：3

作者：

Seo, Woo Duck ^{[1
]}

Curtis-Long, Marcus J. ^{[1
]}

Jeong, Seong Hun ^{[1
]}

Jun, Tae Hong ^{[1
]}

Yang, Min Suk ^{[1
]}

Park, Ki Hun ^{[1
]}

机构：

[1] Gyeongsang Natl Univ, Dept Agr Chem, Inst Agr & Life Sci, Div Appl Life Sci,BK Program 21, Jinju 660701, South Korea

来源：

SYNTHESIS-STUTTGART | 2007年 / 02期

基金：

日本学术振兴会;

关键词：

oxazolidin-2-one; intramolecular cyclization; stereoselectivity; A(1,3) strain; alpha-hydroxy-beta-amino acids;

D O I：

10.1055/s-2006-958956

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Valine and alanine were converted into the corresponding alpha-hydroxy-beta-amino acids through intramolecular S(N)2' cyclization. The novel cyclization protocol relied upon the use of N-benzyl-protected carbarnates derived from a-amino acids

引用

页码：209 / 214

页数：6

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