Expression pattern and diagnostic utility of BCL11B in mature T- and NK-cell neoplasms

被引:1
|
作者
Fang, Hong [1 ]
Khoury, Joseph D. [1 ]
Torres-Cabala, Carlos A. [2 ]
Ng, Siok Bian [3 ,4 ]
Xu, Jie [1 ]
El Hussein, Siba [1 ]
Hu, Shimin [1 ]
Vega, Francisco [1 ]
Li, Shaoying [1 ]
Tang, Zhenya [1 ]
Tang, Guilin [1 ]
Medeiros, L. Jeffrey [1 ]
Wang, Wei [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, 1515 Holcombe Blvd, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
[3] Canc Sci Inst Singapore, Singapore, Singapore
[4] Natl Univ Singapore, Dept Pathol, Singapore, Singapore
关键词
BCL11B; immunohistochemistry; lymphoma; T-cell; NK-cell; SIGNATURES DEFINE; LEUKEMIA; CHECKPOINT; SUBTYPES;
D O I
10.1016/j.pathol.2022.04.012
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
BCL11B is an essential transcription factor for T-cell line-age commitment and differentiation, and its dysregulation has been shown to be associated with T-cell tumouri-genesis. In this study, we investigated BCL11B expression by immunohistochemical analysis in 120 cases of mature T-cell lymphoma, 34 B-cell lymphomas, 11 NK-cell neoplasms and 17 reactive cutaneous conditions. All cases of mycosis fungoides (n=23), primary cutaneous CD4+ small/ medium T-cell lymphoproliferative disorder (n=8) and T-prolymphocytic leukaemia (n=6) were positive for BCL11B and the staining intensity was higher than that of reactive T -cells. Fourteen of 15 (93%) cases of angioimmunoblastic T -cell lymphoma, 10 of 12 (83%) T-large granular lymphocytic leukaemia and 14 of 20 (70%) peripheral T-cell lymphoma, not otherwise specified, were also positive for BCL11B with an intensity comparable to reactive T-cells. Other T-cell neoplasms were uncommonly positive including one of three (33%) cases of primary cutaneous gamma delta T -cell lymphoma, one of four (25%) cases of subcutaneous panniculitis-like T-cell lymphoma, one of four (25%) cases of hepatosplenic T-cell lymphoma, and one of 20 (5%) cases of anaplastic large cell lymphoma (8 ALK-positive, 12 ALK-negative). T-cells in reactive cutaneous infiltrates were also positive for BCL11B, but staining intensity was much weaker than in mycosis fungoides. All NK-cell (n=11) and B-cell neoplasms (n=34) were negative for BCL11B. In conclusion, BCL11B shows a distinct expression pattern in various T-cell neoplasms. BCL11B appears to have utility as another T-cell marker and may be useful in the differ-ential diagnosis of lymphoid neoplasms.
引用
收藏
页码:893 / 899
页数:7
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