Synthesis of β-Lactam-containing Pyrido[3′,2′:4,5]thieno[3,2-e][1,4] diazepines

被引：3

作者：

Stroganova, Tatyana A. ^{[1
]}

Vasilin, Vladimir K. ^{[1
]}

Kovalenko, Georgy A. ^{[1
]}

Krapivin, Gennady D. ^{[1
]}

机构：

[1] Kuban State Technol Univ, Moskovskaya St 2, Krasnodar 350072, Russia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 54卷 / 06期

关键词：

ASYMMETRIC-SYNTHESIS; CYCLOADDITION; KETENE; IMINE; 1,4-BENZODIAZEPINES; INHIBITORS;

D O I：

10.1002/jhet.2936

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel tricyclic 1,4-diazepine derivatives pyrido[3',2 '':4,5]thieno[32-e][1,4]diazepin-2-ones have been synthesized. Azetidin-2-one moiety has been incorporated into the 1,4-diazepine scaffold by [2 + 2] cycloaddition of functionalized ketenes to imine C=N bond, and several tetracyclic azetodiazepines which can be considered as potential compounds of biological interest have been prepared. Stereoselectivity of the cycloaddition was proved by NMR and X-ray analysis data.Novel tricyclic 1,4-diazepine derivatives pyrido[3',2 '':4,5]thieno[32-e][1,4]diazepin-2-ones have been synthesized. Azetidin-2-one moiety has been incorporated into the 1,4-diazepine scaffold by [2 + 2] cycloaddition of functionalized ketenes to imine C=N bond, and several tetracyclic azetodiazepines which can be considered as potential compounds of biological interest have been prepared. Stereoselectivity of the cycloaddition was proved by NMR and X-ray analysis data.

引用

页码：3202 / 3207

页数：6

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