Avidity of anti-β2-glycoprotein I antibodies in patients with antiphospholipid syndrome

被引：19
|
作者：
Cucnik, S. [1 ]
Kveder, T. [1 ]
Artenjak, A. [1 ]
Gallova, Z. Ulcova [2 ]
Swadzba, J. [3 ]
Musial, J. [3 ]
Iwaniec, T. [3 ]
Stojanovich, L. [4 ]
Alessandri, C. [5 ]
Valesini, G. [5 ]
Avcin, T. [6 ]
Tervaert, J. W. Cohen [7 ]
Rozman, B. [1 ]
Bozic, B. [1 ,8 ]
机构：
[1] Univ Med Ctr Ljubljana, Dept Rheumatol, SI-1000 Ljubljana, Slovenia
[2] Charles Univ Prague, Sch Med, Dept Gynecol & Obstet, Plzen, Czech Republic
[3] Jagiellonian Univ, Coll Med, Dept Med, Krakow, Poland
[4] Univ Belgrade, Univ Med Ctr, Belgrade 11001, Serbia
[5] Univ Roma La Sapienza, Dipartimento Med Interna & Specialita Med, Rome, Italy
[6] Univ Childrens Hosp Ljubljana, Univ Med Ctr, Dept Allergol Rheumatol & Clin Immunol, Ljubljana, Slovenia
[7] Maastricht Univ, Med Ctr, Div Clin & Expt Immunol, Dept Internal Med, Maastricht, Netherlands
[8] Univ Ljubljana, Fac Pharm, Chair Clin Biochem, Ljubljana, Slovenia
来源：
LUPUS | 2012年 / 21卷 / 07期
关键词：
anti-beta 2-glycoprotein I antibodies; avidity; chaotropic test; thrombosis; CLASSIFICATION; CRITERIA;
D O I：
10.1177/0961203312440057
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Antibodies against beta(2)-glycoprotein I (anti-beta(2)GPI) are one of the hallmarks of the antiphospholipid syndrome (APS). However, they are heterogenic regarding their epitope specificity, pathogenic mechanisms and their avidity. In the current study we present some outstanding issues about avidity of anti-beta(2)GPI antibodies. Our results confirmed that high avidity anti-beta(2)GPI are associated with thrombosis and APS, while in low avidity anti-beta(2)GPI group nonAPS (predominantly systemic lupus erythematosus) patients prevailed. Lupus (2012) 21, 764-765.
引用
收藏
页码：764 / 765
页数：2
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